10/21 | Tubau-Juni, N., Hontecillas, R., Leber, A. et al. First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis.. (opens in a new tab) Sci Rep. vol. 11, no. 19827, October 21, 2021.
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5/21 | BT-11 (omilancor), a first-in-class, topical therapeutic for psoriasis, ameliorates disease severity and inflammation through activation of LANCL2 pathway. (opens pdf document in a new tab) 2021 American Association of Immunologists (AAI) Annual Meeting. May 10, 2021.
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5/19 | The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial. (opens in a new tab) Inflammatory Bowel Diseases. May 11, 2019.
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5/19 | Validation of lanthionine synthetase C-like 2 (LANCL2) as a therapeutic target for systemic lupus erythematosus. (opens in a new tab) The Journal of Immunology. May 1, 2019.
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4/19 | Oral Treatment with BT-11 Ameliorates Inflammatory Bowel Disease by Enhancing Regulatory T Cell Responses in the Gut. (opens in a new tab) The Journal of Immunology. April 1, 2019.
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2/19 | Nonclinical Toxicology and Toxicokinetic Profile of an Oral Lanthionine Synthetase C-Like 2 (LANCL2) Agonist, BT-11. (opens in a new tab) International Journal of Toxicology. February 21, 2019.
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5/18 | Tu1739 – Translation of Immunometabolic Mechanisms of Bt-11 to Humans with Crohn’s Disease. (opens in a new tab) AGA Journals. May 2018.
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4/18 | Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms. (opens in a new tab) Inflammatory Bowel Diseases. April 28, 2018.
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11/16 | An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. (opens in a new tab) ACS Publications. November 4, 2016.
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5/16 | Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn’s Disease. (opens in a new tab) International Journal of Toxicology. May 26, 2016.
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4/15 | Mo1691 Lanthionine Synthetase C-Like Receptor 2 (LANCL2): A Novel Therapeutic Target for Inflammatory Bowel Disease. (opens in a new tab) AGA Journals . April 2015.
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