Identifying novel pathways at the interface of immunity and metabolism

Publications

Landos NX-13 & NLRX1 Publications

Date Title
A Phase 1b Study to Evaluate Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of the Nucleotide-binding oligomerization domain, Leucine rich Repeat containing X1 (NLRX1) agonist NX-13 in Ulcerative Colitis. (opens in a new tab) Journal of Crohn's and Colitis, Volume 17, Issue Supplement 1. (Publication P577). .
Safety and Tolerability of NX-13 in a Randomized, Double-Blind Placebo Controlled Phase I Study in Normal Healthy Volunteers. (opens in a new tab) Safety and Tolerability of NX-13 in a Randomized, Double-Blind Placebo Controlled Phase I Study in Normal Healthy Volunteers. (Publication P0480). .
Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells. (opens in a new tab) The Journal of Immunology. .
Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1. (opens in a new tab) Drug and Chemical Toxicology . .
Su1818 – Preclinical Efficacy and Safety of Nx-13: A Novel Nlrx1-Targeting Immunometabolic Therapeutic for Crohn’s Disease and Ulcerative Colitis. (opens in a new tab) AGA Journals . .
NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host-Gut Microbiota Interactions during Inflammatory Bowel. (opens in a new tab) Disease Front Immunol. .
NLRX1 Regulates Effector and Metabolic Functions of CD4+ T Cells. (opens in a new tab) J Immunol. .

Landos LABP-69 & PLXDC2 Publications