The NLR (nucleotide-binding domain, leucine rich containing) family of proteins contributes to the regulation of innate and adaptive immunity. Landos has identified NLRX1 as a mitochondria-associated receptor, which serves to control and negatively regulate many of the processes induced by inflammasome activation. The effects of NLRX1 activation include decreased differentiation of effector CD4+ T cells and increased mitochondrial metabolism in immune cells. Furthermore, NLRX1 activation decreases NF-kappa B activity and a wide range of cytokines, including CD4+ T cells and those of myeloid origin.