Preclinical Research Scientist – Autoimmunity

Full Time
Blacksburg, Va
Posted 3 weeks ago

Position Summary:


The preclinical research scientist (RS) – Autoimmunity will be involved in conducting research programs directed at identifying new therapeutic targets and developing new product candidates hitting these targets for the treatment of autoimmune diseases. The RS will write scientific publications, grant and patent applications and investigational new drug (IND) applications. We seek a highly motivated and innovative RS with experience in immunology, cell and molecular biology, and immunometabolism to work with our team on cell-based assays and animal models to drive drug discovery in autoimmune diseases. The successful candidate will work in a team setting and be responsible for cell culture, assay execution support and implementing a broad set of biomarker discovery, PK/PD, animal modeling techniques, and translational studies in primary specimens from autoimmune disease patients plus IND-enabling and clinical studies. The RS will be aligned with four fundamental pillars of Landos’ entrepreneurial corporate culture: 1) Be bold and decisive, 2) Never give up, 3) Be solution-oriented, and 4) Do the impossible.




Experimental Design: Generate and test novel experimental hypotheses to advance discovery-based R&D at Landos. Propose controlled designs capable of robustly testing respective hypotheses to draw conclusions relevant to drug development research. Conduct research studies from in vitro to animal models of autoimmune disease to translational and clinical trials.


Data analysis: Leverage the LANCE drug development platform to help identify new therapeutic targets and develop new drugs. Utilize established and novel methods to analyze data. Data types will include but are not limited to flow cytometry results, high-throughput sequencing, proteomics, protein biochemistry assays, and histopathology.


Data communication and reporting: Develop lab protocols. Provide detailed study reports of experimental results. Generate figures, presentations and publications to communicate results with scientific community, investors, and collaborators. Support the development of peer reviewed scientific publications, patents and grants relevant to ongoing research.


Laboratory Procedures: Perform various standard experimental assays including quantitative real-time PCR, Western blot, flow cytometry, and ELISA. Work in sterile conditions to conduct cell culture experiments and maintain the growth of cell lines. Express and purify recombinant protein. Collect and analyze generated data.


Personnel Training: Training of Landos personnel on laboratory upkeep, experimental assays and research projects. Guide the personnel resourcing of projects and tasks.


Animal Procedures: Conduct various IACUC approved laboratory animal procedures and techniques for Landos projects including but not limited to basic rodent handling, oral gavage, intraperitoneal injection, blood collection, and euthanasia. Interact with animal facility personnel to maintain organization and compliance of animal facilities. Will design new animal studies for projects related to therapeutic efficacy or mechanisms of action of new drugs for autoimmune diseases.


Teamwork: Work independently and collaboratively in a matrixed environment. Be able to successfully work with other Landos team members in experiments.


Regulatory Compliance: Support regulatory compliance efforts as instructed by the senior leadership in accordance with IACUC, IBC, and IRB protocols. Implement, organize and maintain regulatory compliance records.


Record keeping: Keep detailed records of all activities, record these activities in ASANA, Google Drive, laboratory notebook, the Landos Colony Management System (CMS), and Labkey. Provide weekly updates of the Landos research progress to the Scientific Director, and Landos team. Maintains confidentiality of all data, information and knowledge.


Product Development: Support for product development ranging from development, interfacing with CROs, CMOs, and other vendors for IND-enabling and clinical studies. He will help support sales and marketing activities following NDA approval in the commercialization phase.


Maintain the confidentiality of all the company deliberations and plans.


FLSA Status:  Exempt


Reports to:  CSO (see Organizational Chart)


Any other tasks requested by the President and CEO.


Act in accordance with Landos’ policies.


Important skills:

  • A+ attitude, great work ethic, and attention to detail
  • Previous drug development experience.
  • Capacity to foster a fast-paced, yet supportive, working environment
  • Organized with ability to multi-task
  • Laboratory assays: real-time PCR, Western blot, and ELISA
  • SOP development, record keeping skills
  • Knowledge of mucosal immunity and inflammatory processes in autoimmune diseases.
  • Multi-parameter flow cytometry staining and analysis
  • Analytical software: PRISM, FACS Diva, FlowJo, Excel, SAS, IPA
  • Demonstrated experience analyzing, interpreting and presenting experimental data and developing reports, peer-reviewed publications, grants, patents.
  • IACUC, IBC, and IRB protocol writing experience.

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